REGULATION OF PRE-MRNA SPLICING: INDISPENSABLE ROLE OF POST-TRANSLATIONAL MODIFICATIONS OF SPLICING FACTORS


The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model

Abstract Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are closely related nuclear receptors with overlapping regulatory functions in xenobiotic Headboard clearance but distinct roles in endobiotic metabolism.Car activation has been demonstrated to ameliorate hypercholesterolemia by regulating cholesterol metabolism and bile

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